A likely target of M is the transformer ( tra) gene, which is required for female development in L. Felix Guerrero (USDA-ARS partner) commented on the manuscript and provided a sequence of a small fragment of the Chtra gene.Ĭompeting interests: The authors have declared that no competing interests exist.Ī Y-linked male determining gene ( M) determines sex in the Australian sheep blowfly Lucilia cuprina. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.įunding: This research was supported by a specific cooperative agreement between the USDA-ARS and NCSU and start-up funds to MJS from the College of Agriculture and Life Sciences, NCSU. Received: JAccepted: JanuPublished: February 7, 2013Ĭopyright: © 2013 Li et al. hominivorax, a major livestock pest, will facilitate the development of a “male-only” strain for genetic control programs.Ĭitation: Li F, Vensko SP II, Belikoff EJ, Scott MJ (2013) Conservation and Sex-Specific Splicing of the transformer Gene in the Calliphorids Cochliomyia hominivorax, Cochliomyia macellaria and Lucilia sericata. The isolation of the tra gene from the New World screwworm fly C. RNAi experiments showed that tra is required for female development in L. sericata embryos, the male tra transcript was first detected at around the time of cellular blastoderm formation. We propose a model for sex specific regulation of tra splicing that incorporates the conserved features identified in this study. The most conserved regions are around the exon/intron junctions, the 3′ end of the intron and near the cluster of TRA/TRA2 sites. However, overall the sex-specific intron sequences are poorly conserved in closely related blowflies. The tra genes all contain a single TRA/TRA2 site in the male exon and a cluster of four to five sites in the male intron. The blowfly adult male and female transcripts differ in the choice of splice donor site in the first intron, with males using a site downstream of the site used in females. With the aim of identifying conserved motifs that may play a role in tra sex-specific splicing, here we have isolated and characterized the tra gene from three additional blowfly species, L. cuprina gene suggested that tra splicing is auto-regulated as in medfly and housefly. The presence of six predicted TRA/TRA2 binding sites in the sex-specific female intron of the L. tra transcripts are sex-specifically spliced such that only the female form encodes full length functional protein. The sci-fi flick features Adrien Brody, Sarah Polley, and Delphine’s fab flesh! As Dren, the skintastic starlet embodies a genetic experiment gone wrong.Transformer (TRA) promotes female development in several dipteran species including the Australian sheep blowfly Lucilia cuprina, the Mediterranean fruit fly, housefly and Drosophila melanogaster. Chanéac could be seen on the big screen in the R-rated picture Splice (2010). She also starred in the boob tube miniseries Laura, le compte à rebours a commencé (2006) and offered a topless turn in the action show Transporter: The Series (2012). Indeed, the beautiful broad is best known abroad for playing Pauline in the French sitcom La vie devant nous (2002). Throughout the years, she’s worked as a disc jockey in clubs, acted in stage productions ( Welcome à Saint Tropez), performed in films ( The Pink Panther, For the Love of Money, L’amour vache, In extremis), and on TV ( Madame Hollywood, Louis la brocante, Lola, qui es-tu Lola?, Un homme en colère). Not just a pretty face and bitchin’ bod, Mademoiselle Chanéac possesses plenty of talents. Is there anything sexier than a brunette ingénue speaking French? All you have to do is watch the foreign films of Anouk Aimée, Isabelle Adjani, Juliette Binoche, Marion Cotillard, and Audrey Tautou to know these worldly women are arousing enough to erect an Eiffel Tower in your pants! Oh, and don’t forget to add Delphine Chanéac to this list of irresistible French actresses.
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